ICPH2019

Thursday, November 28

Pre-symposium14:00-15:30【Room B】

ICPH–Japan Polyphenol Society / Japanese Sociefy of Catechinology Joint Symposium

Chair: Junji Terao; (Japan)

PSY-1
14:00

Circulating (poly)phenol metabolites mediate vascular benefits of berries

: Ana Rodriguez-Mateos; (UK)

PSY-2
14:30

Curcumin as a promising cancer preventive polyphenol

: Hye-Kyung Na; (Korea)

PSY-3
15:00

Disclosing how phenolic metabolites modulate brain inflammation

: Claudia Nunes dos Santos; (Portugal)

Opening Lecture 116:00-16:45【Room A】

Chair: Hitoshi Ashida; (Japan)

OL1
16:30

Perspective on polyphenol research in human health

: Junji Terao; (Japan)

Opening Lecture 216:45-17:30【Room A】

Chair: Kayoko Shimoi; (Japan)

OL2
17:00

Metabolomics for assessment of true exposure to phytochemicals and consideration of individual metabotypes

: Claudine Manach; (France)

Friday, November 29

Plenary Lecture 18:30-9:30【Room A】

Chair: Alan Crozier; (USA)

PL1
8:30

Flavonoid induced cognition: Intake requirements and the role of the vascular system

: Jeremy P.E. Spencer; (UK)

Plenary Lecture 29:00-9:30【Room A】

Chair: Naomi Osakabe; (Japan)

PL2
9:00

Polyphenols at the gastrointestinal tract: impact on metabolic disorders

: Patricia I. Oteiza; (USA)

Symposium 110:00-11:30【Room A】

Brain Health and Cognitive Function

Chairs: Barbara Shukitt-Hale; (USA)

: Rie Mukai; (Japan)

SY01-1
10:00

Zoom on the link between diet and brain health: how phenolic metabolites modulate brain inflammation

: Cláudia Nunes dos Santos; (Portugal)

SY01-2
10:20

The effects of an acute wild blueberry intervention on cognition in 7-10 year old children using expanded memory and executive function task batteries

: Claire M. Williams; (UK)

SY01-3
10:40

Fisetin and its derivatives for the treatment of age-associated dementia

: Pamela Maher; (USA)

SY01-4
11:00

Effects of polyphenol-rich plants on physiological responses for social stress

: Hiroyuki Sakakibara; (Japan)

SY01-5
11:15

Protective effects of green tea catechin, epigallocatechin gallate and its metabolites on age-related cognitive dysfunction: mechanism of action

: Monira Pervin; (Japan)

Symposium 213:30-15:00【Room A】

Metabolic Syndrome

Chairs: Kevin D. Croft; (Australia)

: Nobuyuki Takahashi; (Japan)

SY02-1
13:30

Associations between dietary polyphenol intake and metabolic diseases: findings from the EPIC study

: Raul Zamora-Ros; (Spain)

SY02-2
13:50

Host-microbe interplay in the cardiometabolic benefits of dietary polyphenols

: André Marette; (Canada)

SY02-3
14:10

Kidney damage in metabolic syndrome: prevention by the flavonoid (-)-epicatechin

: Monica Galleano; (Argentina)

SY02-4
14:30

Anti-obesity and anti-diabetic effects of flavan-3-ols

: Hitoshi Ashida; (Japan)

SY02-5
14:50

Polyphenol intake and metabolic syndrome risk in European adolescents: the HELENA study

: Ratih Wirapuspita Wisnuwardani; (Belgium)

Symposium 315:30-17:00【Room A】

Gut Microbiota

Chairs: Patricia I. Oteiza; (USA)

: Kyuichi Kawabata; (Japan)

SY03-1
15:30

Urolithins produced by gut microbial bioactivation of ellagitannins. Are they neuroactive metabolites?

: Francisco A. Tomás-Barberán; (Spain)

SY03-2
15:50

Dietary polyphenols improve glucose metabolism by bile acid-induced inhibition of farnesoid-X receptor activity

: Diana Roopchand; (USA)

SY03-3
16:05

Physiological functions due to the gut homeodynamics of polyphenols

: Toshihiko Shoji; (Japan)

SY03-4
16:25

Modulating gut microbial bile acid metabolism with polyphenol rich foods for improved health

: Kieran Tuohy; (Italy)

SY03-5
16:45

Lactobacillus boost bioavailability of polyphenols in onion

: Miriam Dormeyer; (Germany)

Symposium 410:00-11:30【Room B】

Chemical Approches and Tools

Chairs: Alyson E. Mitchell; (USA)

: Dragan Milenkovic; (France)

SY04-1
10:00

The bioavailability of orange juice flavanones

: Alan Crozier; (USA)

SY04-2
10:20

Biosynthesis of hetero-conjugates of quercetin using xenobiotic enzymes expressing yeast

: Shinichi Ikushiro; (Japan)

SY04-3
10:40

Application of ¹H-qNMR to determine response factors between compounds for improving analytical results obtained from chromatography

: Yuzo Nishizaki; (Japan)

SY04-4
11:00

New simple HPLC-UV/LC-MS analysis of silymarin flavonolignans: quantification of previously undetectable and/or non-separable components

: Katerina Valentova; (Czechia)

SY04-5
11:10

A new natural turmeric extract formula increased curcumin(oids) bioavailability in healthy humans

: Pascale E Fança-Berthon; (France)

Symposium 513:30-15:00【Room B】

Omics and Analytical Approachs

Chairs: Cristina Andres-Lacueva; (Spain)

: Yoichi Sakakibara; (Japan)

SY05-1
13:30

Systems biology network analysis of nutri(epi)genomic changes to decipher molecular mechanisms of action of polyphenols

: Dragan Milenkovic; (France)

SY05-2
13:50

Metabolic profiling for the bioactivity evaluation of green tea and the selection of bioactivity-related chemical combinations

: Yoshinori Fujimura; (Japan)

SY05-3
14:10

(-)-Epicatechin metabolome and its application for the development of nutritional biomarkers for flavanol intake

: Javier I Ottaviani; (USA)

SY05-4
14:30

Discovery of novel flavonoids in nature by metabolome analyses and the FlavonoidSearch system

: Nozomu Sakurai; (Japan)

SY05-5
14:45

Effect of citrus flavanone metabolites on oxidative stress and proteomic profile in pancreatic β-cells

: Sara L. Anacleto; (Brazil)

Symposium 615:30-17:00【Room B】

New Perspective of Polyphenol Targets

Chairs: Young-Joon Surh; (Korea)

: Hiroyuki Sakakibara; (Japan)

SY06-1
15:30

Astringency induces sympathomimetic physiological changes through excitation of locus correleus - noradrenaline system

: Naomi Osakabe; (Japan)

SY06-2
15:50

Sulforaphane synergizes with JQ1 to inhibit colorectal cancer: might dietary polyphenols serve as natural alternative epigenetic ‘reader’ inhibitors?

: Roderick Dashwood; (USA)

SY06-3
16:10

Identification of bitter taste receptors that respond to tea catechins

: Masataka Narukawa; (Japan)

SY06-4
16:30

Molecular targets of epicatechin: gene expression assessment in Caenorhabditis elegans

: Begoña Ayuda-Durán; (Spain)

SY06-5
16:40

The role of 3,4-dihydroxyphenyl-γ-valerolactone, the gut microbiota metabolite of epicatechin, in reducing insulin resistance

: Jenna Helleur; (UK)

SY06-6
16:50

The effect of kaempferol on glucose uptake in L6 myotubes

: Hao Jiang; (Japan)

Saturday, November 30

Plenary Lecture 38:30-9:30【Room A】

Chair: Mariko Uehara; (Japan)

PL3
8:30

Metabolomics based dietary biomarkers in Nutritional Epidemiology. Challenges & opportunities in polyphenol research

: Cristina Andres-Lacueva; (Spain)

Plenary Lecture 49:00-9:30【Room A】

Chair: Junji Terao; (Japan)

PL4
9:00

Mechanistic insights on the action of polyphenols against type 2 diabetes from in vitro cellular and in vivo intervention studies

: Gary Williamson; (Australia)

Symposium 710:00-11:30【Room A】

Bioavailability and Metabolism

Chairs: Gary Williamson; (Australia)

: Shinichi Ikushiro; (Japan)

10:00

Overview

SY07-1
10:10

Bioavailability of anthocyanins from fermented red cabbage

: Mariusz Piskula; (Poland)

SY07-2
10:30

Phenyl-γ-valerolactones and their derived phenolic acids: the missing link in the health effects of flavan-3-ols?

: Pedro Mena; (Italy)

SY07-3
10:50

Food processing strategies to modulate bioavailability and bioefficacy of chlorogenic acids in humans

: Diane Zimmermann; (Switzerland)

SY07-4
11:10

Lymphatic transport of flavonoid glycosides after intestinally administration in rats

: Kaeko Murota; (Japan)

Symposium 813:30-15:00【Room A】

Tea Catechin and Function

Chairs: Chung S. Yang; (USA)

: Yoshinori Fujimura; (Japan)

13:00

Overview

SY08-1
13:35

Laboratory studies on the mitigation of metabolic syndrome by green tea

: Joshua D. Lambert; (USA)

SY08-2
13:55

67-kDa laminin receptor signaling mediates the bioregulatory effects of green tea polyphenol EGCG

: Hirohumi Tachibana; (Japan)

SY08-3
14:15

EGCG-rich green tea extract ameliorates fatty liver and weight gain in mice by activating the Sirt1 and AMPK pathway

: Byung-Hyun Park; (Korea)

SY08-4
14:35

Synthesis of EGCg and nobiletin toward chemical biology investigations

: Toshiyuki Kan; (Japan)

Symposium 915:30-17:00【Room A】

Cacao: Intervention and Epidemiology

Chairs: Naomi Osakabe; (Japan)

: Amin Ismail; (Malaysia)

SY09-1
15:30

Assessing the respective contributions of cocoa bioactives in mediating cardiovascular effects in humans

: Christian Heiss; (UK)

SY09-2
15:55

Population-based investigations of bioactives and health: A case study on flavanols

: Hagen Schroeter; (USA)

SY09-3
16:20

Cocoa polyphenols: In vitro and in vivo evidence for mechanisms decreasing the risk of heart disease

: Joe Vinson; (USA)

SY09-4
16:40

Relationship of dark chocolate intake with physical function in Japanese subjects

: Midori Natsume; (Japan)

Symposium 1010:00-11:30【Room B】

Anthocyanins and Procyanidins

Chairs: Claudine Manach; (France)

: Toshihiko Shoji; (Japan)

SY10-1
10:00

The tannin fractions of polyphenol berry extracts regulate glycemia by modulating the gut microbiota and an improving the gut barriers function

: Yves Desjardins; (Canada)

SY10-2
10:20

Variability in vascular response to dietary (poly)phenols: role of gut microbial metabolism

: Ana Rodriguez-Mateos; (UK)

SY10-3
10:40

Anthocyanin and non-anthocyanin pigments from colored seed coat of edible beans

: Kumi Yoshida; (Japan)

SY10-4
11:00

Cancelled

SY10-5
11:20

Cinnamtannin A2 reduces anxiety behavior induced by social defeat stress and improves spatial memory

: Yasuyuki Fujii; (Japan)

Symposium 1113:30-15:00【Room B】

Cardiovascular Health

Chairs: Kazuo Kondo; (Japan)

: Paul A. Kroon; (UK)

SY11-1
13:30

Potential of anthocyanin-rich food to prevent endothelial senescence and improve vascular health

: Valérie Schini-Kerth; (France)

SY11-2
13:50

Anthocyanins - importance of metabolism in explaining the cardiometabolic health effects

: Aedín Cassidy; (Ireland)

SY11-3
14:10

Cardiovascular health: which flavonoids and who should be consuming them?

: Jonathan M. Hodgson; (Australia)

SY11-4
14:30

Dietary intake of polyphenols in Japan and its role in the prevention of cardiovascular diseases

: Yoshimi Kishimoto; (Japan)

SY11-5
14:50

The effects of chronic cocoa flavanol supplementation on vascular function in healthy older adults

: Amy Rees; (UK)

Symposium 1215:30-17:00【Room B】

Polyphenols in Asian Foods

Chairs: Lucy Sun Hwang; (Taiwan)

: Hideyuki Ito; (Japan)

SY12-1
15:30

Dietary polyphenols protect against oxidative stress-induced gastrointestinal mucosal damage

: Gow-Chin Yen; (Taiwan)

SY12-2
15:45

Polyphenols in Asian foods regulate senescence marker protein 30

: Mariko Uehara; (Japan)

SY12-3
16:00

Evidence-based traditional medicinal-plants and foods

: Intan S. Ismail; (Malaysia)

SY12-4
16:15

Ellagitannins from pomegranate and their antiglycation properties

: Hideyuki Ito; (Japan)

SY12-5
16:30

Diversity on absorption and metabolism of urushiol derivatives

: Jae-Hak Moon; (Korea)

SY12-6
16:45

Combined feeding of α-glycosyl-isoquercitrin and soluble soybean fiber prevents glucose intolerance in rats

: Aphichat Trakooncharoenvit; (Japan)

Sunday, December 1

Plenary Lecture 58:30-9:00【Room A】

Chair: Cesar G. Fraga; (Argentina)

PL5
8:30

Whodunnit? Teasing apart the effects of ingested polyphenols versus their gut microbiota metabolites

: Paul A. Kroon; (UK)

Plenary Lecture 69:00-9:30【Room A】

Chair: Toshihiko Shoji; (Japan)

PL6
9:00

Development of functional green tea and the use of functional food labeling system in Japan

: Mari Maeda-Yamamoto; (Japan)

Symposium 1310:00-11:30【Room A】

Learning from Functional Phytochemicals

Chairs: Yoshimasa Nakamura; (Japan)

: Noriyuki Miyoshi; (Japan)

SY13-1
10:00

Chrono-nutrition from mice to humans -Timing effect of diet fibers on body glucose level, fecal SCFA and microbiota-

: Shigenobu Shibata; (Japan)

SY13-2
10:20

Hydroxycoumarin OT-55 kills CML cells alone or in synergy with Imatinib or Synribo: involvement of ER stress and DAMP release

: Marc Diederich; (Korea)

SY13-3
10:40

Avenanthramides as antioxidant and antiinflammatory agents

: Li Li Ji; (USA)

SY13-4
11:00

Rare sugar D-allulose ameliorates arrhythmic overeating, obesity and diabetes by <intestinal GLP-1 release ? vagal afferents ? brain> axis

: Yusaku Iwasaki; (Japan)

SY13-5
11:20

Evaluation of antimicrobial release from biodegradable films, foreseeing application as food packaging material

: Samar Elshamy; (Japan)

Symposium 1410:00-11:30【Room C】

Multifunctional Effects of Polymethoxy Flavonoids and Their Mechanism of Action

Chairs: Je Tae Woo; (Japan)

: Shizuo Yamada; (Japan)

SY14-1
10:00

Process for the production of high purity nobiletin from Citrus depressa (Shikuwasa) and its various biological activities

: Je Tae Woo; (Japan)

SY14-2
10:20

Separation of 5-O-demethyl nobiletin from Citrus depressa, Shikuwasa and its evaluation of alcoholic fatty liver damage prevention

: Jae Gyu Park; (Korea)

SY14-3
10:40

Effect of Kaempferia parviflora extract on obesity and physical activity

: Riyo Awa; (Japan)

SY14-4
11:00

Nobiletin, a flavone from Shiikuwasa (Citrus depressa), alleviates urinary dysfunction

: Shizuo Yamada; (Japan)

Symposium 1510:00-11:30【Room B】

Polyphenols: The Road from Plants to Functional Foods (ICoFF Pre-symposium)

Chairs: Christine Morand; (France)

: Kevin D. Croft; (Australia)

10:00

Introduction

SY15-1
10:05

Polyphenols and digestion process: Targeting the multiple gut functionalities

: Vincenzo Fogliano; (The Netherlands)

SY15-2
10:25

Bioavailability of cocoa flavan-3-ols

: Alan Crozier; (USA)

SY15-3
10:45

Vascular health benefits of high flavonoid apples

: Jonathan M. Hodgson; (Australia)

SY15-4
11:05

Identification of the biochemical mechanisms involved in the health benefits of plant (poly)phenols

: Cesar G. Fraga; (Argentina/USA)

11:25

Closing

Special Lecture12:45-13:30【Room B】

SL
12:45

Best practices for success in publishing your work in AJP - endocrinology & metabolism

: Andre Marette; (USA)

Joint Keynote Lectures14:00-17:45

Starter: Hitoshi Ashida; (Japan)

Joint Keynote Lecture 114:00-14:35【Portopia Hall】

Chair: Akira Murakami; (Japan)

KL1

Anticarcinogenic and chemopreventive substances in food: An update

: Young-Joon Surh; (Korea)

Joint Keynote Lecture 214:35-15:10【Portopia Hall】

Chair: Naomi Osakabe; (Japan)

KL2

Cancer prevention by food-derived phytochemicals

: Zigang Dong; (USA)

Joint Keynote Lecture 315:10-15:45【Portopia Hall】

Chair: Hiroshige Itakura; (Japan)

KL3

Novel physiological function of bile acid and a food factor that mimics its function

: Ryuichiro Sato; (Japan)

Joint Keynote Lecture 416:00-16:35【Portopia Hall】

Chair: Kayoko Shimoi; (Japan)

KL4

Contribution of plant food bioactives in promoting health effects of plant foods - why look at interindividual variability?

: Christine Morand; (France)

Joint Keynote Lecture 516:35-17:10【Portopia Hall】

Chair: Junji Terao; (Japan)

KL5

Dietary polyphenols for cardiovascular health

: Kevin D. Croft; (Australia)

Joint Keynote Lecture 617:10-17:45【Portopia Hall】

Chair: Kenji Sato; (Japan)

KL6

Phenolipids in food: bioactivities and health effects

: Fereidoon Shahidi; (Canada)

Program